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Public Health Research / Implementation Research
Implementation Research 5 min readReviewed 24 October 2026

How to Formulate Implementation Research Questions from Programme Gaps

Convert coverage gaps, stock-outs and supervision findings into focused implementation research questions with a defined setting, strategy, outcome and feasible scope.

Editorial context

Adapted and summarized by PHC-Nepal from the uploaded WHO/TDR training slides Module2_Chapter3.pdf, developed with technical support from EPFL. The upload does not establish a publication date. This is an independent educational summary, not a WHO-endorsed course or certificate. Historical infectious-disease examples illustrate research methods; they are not current Nepal statistics or clinical protocols.

Key points

  • Start with a documented implementation gap rather than a preferred solution.
  • Ask what could be tested to address the gap.
  • Coverage is not the same as consistent use or individual adherence.
  • Prioritize questions by relevance, equity, feasibility and decision value.

Start with two questions

The chapter asks which programme implementation challenges need attention and which responses could be tested to address them. This separates the observed problem from the proposed solution. A topic such as ‘community health workers’ is too broad to function as a research question.

A useful question describes a specific gap in a specific setting. For instance, ‘Which parts of the resupply workflow contribute to repeated stock-outs in participating facilities?’ is more actionable than ‘How can we improve the health system?’

Use programme evidence

Questions may emerge from progress reports, HMIS trends, supervision or population surveys. A team should first establish whether a finding reflects actual delivery, measurement quality or both.

The module's historical examples include declining net use after sustained coverage and gaps between reported medicine distribution and repeated individual use. The lesson is to ask what the indicator truly measures: distribution does not guarantee correct or continued use.

From a gap to a testable strategy

Once the bottleneck is understood, ask whether a defined strategy can address it. A hypothetical resupply study might compare scheduled joint stock review with existing reporting arrangements and assess stock availability, staff workload and cost.

Do not make the strategy unnecessarily complex. If several activities are combined, describe their components and intended mechanisms. Otherwise a change in outcomes will be difficult to interpret or reproduce.

Prioritize before writing a protocol

Research should answer a decision that implementers and communities actually face. Consider the seriousness of the gap, potential benefit for underserved groups, uncertainty, available resources and whether findings can inform action.

  • Is the gap supported by credible data?
  • Who would use the answer and what decision would change?
  • Can the question be investigated within the time and budget?
  • Are relevant permissions, safeguards and partnerships feasible?
  • Could a proposed strategy worsen inequity or burden staff?

Keep clinical examples in their context

The slides discuss malaria testing, pregnancy prevention services and medicine distribution as examples of implementation questions. They are not prescribing instructions. A research proposal involving new tasks, tests or medicines requires appropriate clinical governance and current national authorization.

For a Nepal proposal, use the current programme policy and locally collected evidence. Label hypothetical examples clearly and avoid importing historical treatment schedules or foreign coverage targets into a present-day protocol.

Sources and further reading

Use the linked institutions for current definitions, regulations, programmes and statistics.

Related learning note

Implementation ResearchWhat Is Implementation Research? Concepts, Scope and Three Core PhasesUnderstand implementation research, how it differs from intervention and health systems research, and how teams define problems, design strategies and test delivery in real settings.

Educational notice: This article summarizes historical and public-health material. It does not replace current national protocols, clinical judgement or care from a qualified professional.